Introduction of freeze-drying sequence and freeze-drying curve:
The lyophilization curve is the relationship between the plate temperature and time in the lyophilization chamber. Generally, the temperature is the ordinate and the time is the abscissa. It reflects the temperature change of the plating layer at different times during the freeze-drying process. The freeze-drying sequence is the opening and closing operation of various equipment at different times during the freeze-drying process.
The connection between the freeze-drying sequence and the freeze-drying curve:
The freeze-drying curve and freeze-drying sequence are not only the basis for the manual operation of the freeze-drying machine but also the basis for the automatic control of the freeze-drying machine operation. For example, when using the cam method and the drum method for automatic control of the freeze-drying machine, the scribing basis of the cam and the drum is the freeze-drying curve and timing. The freeze-drying curve and time sequence are input into the storage of the microcomputer with the operation keyboard according to certain requirements of the microcomputer.
The importance of lyophilization timing and lyophilization curve:
The freeze-dried products of biological products need to have a certain physical form; uniform color, qualified residual moisture content, good solubility, high survival rate or potency, and long shelf life. Therefore, it is not only necessary to control the seedling production process and the sealed storage after lyophilization. More importantly, it is necessary to comprehensively control the parameters of each stage of the freeze-drying process in order to obtain high-quality products. The freeze-drying curve and sequence are the basic basis for freeze-drying process control.
