High Efficiency Lyophilizer

High efficiency lyophilizer

In lyophilized liquid preparations, some are active ingredients for therapeutic effect, and some are other ingredients without therapeutic effect. Generally, the ingredients without therapeutic effect are called freeze-drying protective agent.

Some liquid formulations can be successfully freeze-vacuum dried, while others cannot. In order to successfully freeze-dry certain preparations, or to improve the solubility and stability of freeze-dried products, or to make freeze-dried products have a beautiful shape, etc., some additional substances need to be added to liquid preparations, which are protective agents. Sometimes also called fillers, excipients, buffers, bases, etc. The protective agent must be chemically specific to the lyophilized product.

Some of the effects of protective agents:

1. Microorganisms such as bacteria and viruses need to grow and reproduce in specific culture media, but these culture media and microorganisms are often difficult to separate, and they can be successfully frozen in these culture media. Examples include broth, skim milk, and protein.

2. Some freeze-dried preparations have very low concentration and very little dry matter content. The dried part will be taken away by the sublimation airflow during freeze-drying. In order to increase the concentration and increase the content of dry matter so that the freeze-dried product can form an ideal mass, it is necessary to add filler material to make the concentration of solid matter between 4% and 25%. These fillers or excipients are sucrose, lactose, inositol, skim milk, hydrolyzed protein, dextran, sorbitol, polyvinylpyrrolidone (PVP) and the like.

3. Some biologically active substances are particularly fragile and will be harmed by physical or chemical reasons during freezing and drying, so some protective agents need to be added to reduce the damage during freezing and drying. For example, dimethyl sulfoxide, glycerol, dextran, carbohydrates and PVP, etc.

4. Adding certain substances can increase the disintegration temperature of the product and make the product easy to freeze-dry. They are mannitol, glycine, dextran, xylitol and PVP among others.

5. In order to change the pH of the freeze-dried preparation, so as to increase the eutectic point to facilitate freeze-drying. They are sodium bicarbonate, sodium hydroxide, etc.

6. In order to improve the storage stability of the product, increase the storage temperature and prolong the storage time. They are some antioxidants such as vitamin C, vitamin E, amino acids, sodium thiosulfate, thiourea, lecithin and hydrolyzed protein, etc.

7. Adding certain substances can eliminate free radicals and increase the stability of freeze-dried products. They are amino acids, vitamin K, vitamin C, thiourea, sulfite compounds, sodium aspartate, etc.

According to the chemical composition of the protective agent, it can be divided into the following categories:

1. Complex: skim milk, gelatin, protein and hydrolyzate, polypeptide, yeast, broth, dextrin, methylcellulose, serum, peptone, etc.

2. Salts: sodium thiosulfate, calcium lactate, sodium glutamate, sodium chloride, potassium chloride, sodium sulfate, ammonium acetate, ammonium chloride, etc.

3. Sugars: sucrose, lactose, maltose, glucose, raffinose, fructose, hexose, etc.

4. Alcohols: sorbitol, ethanol, glycerol, mannitol, inositol, xylitol, etc.

5. Acids: citric acid, phosphoric acid, tartaric acid, amino acid, ethylenediaminetetraacetic acid (EDTA), etc.

6. Alkali: sodium hydroxide, sodium bicarbonate, etc.

7. Polymer: dextran, polyethylene glycol, PVP, etc.

8. Others: vitamin C, vitamin E, vitamin K, thiourea, etc.

There are a wide range of protective agents and a wide variety, but there is no very ideal protective agent. There is no one-size-fits-all formulation of protectants for different lyophilized formulations, and the appropriate protectant for each product is determined by trial and error.

Choose High efficiency lyophilizer to save production costs.

Parameter:

Pre-sale:

* As soon as we get your inquiry, we will always reply to your email on time and try our best to recommend you the most suitable freeze dryer. Detailed tech info will also be provided for you.

* We can do sample tests for customers.

After-sale:

* If possible, please do come to our factory and we will teach workers the whole process of freeze-drying. The most appropriate time needed for freeze-drying will be tested by us.

* We will keep in touch with you, to make sure every part of the freeze dryer works well. One-year warranty, free online service for abroad customers.

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