Freeze Dryer In Pharmaceutical Processing

Freeze Dryer In Pharmaceutical Processing

Due to the application of a freeze dryer in pharmaceutical processing, it belongs to low-temperature drying of Chinese medicinal materials, so the food freeze dryer can well retain the original shape and structure in the processing of traditional Chinese medicinal materials. The traditional high-temperature drying process (such as drying and sun drying) breaks the dynamic equilibrium state maintained by the water molecules and various components of Chinese medicinal materials, which is easy to harden the surface of the medicine and collapse the internal tissue, resulting in the final deformation of the medicine.

The Chinese herbal medicine after being freeze-dried at low temperatures can not only maintain the original morphological structure of the material but also make the inside of the medicine porous, making it easier to crush and use as medicine. For example, when Wei Qingxia compared the rehydration ratio, shrinkage rate, and microstructure of astragalus by different drying methods, he found that the astragalus obtained by vacuum freeze-drying has good rehydration performance and can be basically restored to the original state after rehydration, and there is no shrinkage phenomenon after drying. It retains its pre-drying form.

Chumroenphat et al. observed the microstructure of turmeric treated by freeze-drying and other drying methods and found that the surface density of freeze-dried tissue is smaller, the cell structure is relatively complete, and the microstructure of fresh tissue is the closest. Xu Lei et al. observed the internal structure of Gastrodia elata dried by different methods and found that after vacuum freeze-drying, the cell damage was less, and it had a porous honeycomb structure, loose texture, and brittleness, which was convenient for direct consumption.

The freeze dryer in pharmaceutical processing can well retain the original color and luster in the application of Chinese medicinal materials. The color and luster of Chinese medicinal materials are reflected in the pigment components (chlorophyll, carotenoids, anthocyanins, etc.) contained in them. The degradation of pigments affects the final quality of the medicinal materials. Effectively avoid the occurrence of degradation and enhance the sensory value.

For example, after hot air drying and vacuum drying of Dendrobium officinale, the appearance of color changes from bright green to yellowish brown. It may be that the chlorophyll in it is decomposed by heat, and the Medela reaction occurs at high temperatures. The freeze-drying technology is carried out under low-temperature conditions. , which can keep the original color quality of the material well.

Similarly, saffron belongs to a class of water-soluble carotenoids with anti-inflammatory and other pharmacological activities, and is widely present in saffron. Acar et al. found that saffron can not only better retain heat sensitivity after being processed by freeze-drying equipment Volatile components can also reduce the loss of crocin and maintain the original color quality.

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