Freeze-drying Machine Manufacturers
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Freeze-drying Machine Manufacturers

Name:freeze dryer
Size: from 0.5 to 200m²
Highlight: can be customized
Warranty:one year

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Freeze-drying Machine Manufacturers

The freeze-drying technology is different from the previous high-temperature drying technology. It sublimates the moisture of the product under low temperature and low pressure, and can well retain the original biological characteristics and active ingredients of the product. The application of freeze-drying technology in the field of traditional Chinese medicine provides a new possibility for the processing and drying of traditional Chinese medicine. Below, the freeze-drying machine manufacturers have sorted out the main aspects of the medicinal material freeze-drying machine for low-temperature drying of Chinese medicinal materials to retain the original medicinal ingredients:

1. Polysaccharide components Traditional Chinese medicine polysaccharides have pharmacological activities such as promoting immune regulation, anti-oxidation, anti-tumor, and anti-virus, and their physicochemical properties and biological activities depend on spatial structure. Yu Fen et al. summarized the physical and chemical properties and mechanism changes of Chinese medicinal materials during the drying process, and found that the main reasons for the decrease in polysaccharide content included respiration, high temperature degradation, enzymatic degradation and oxidative degradation. Low temperature freeze-drying can not only reduce respiration, but also inhibit the oxidative denaturation of polysaccharides under high temperature conditions.

The effects of different drying methods on the antioxidant capacity of Ganoderma lucidum polysaccharides were compared, and it was found that the polysaccharides obtained by vacuum freeze drying had higher scavenging of hydroxyl radicals, superoxide radicals and 1,1-diphenylene than hot air drying and vacuum drying. Radix-2-trinitrophenylhydrazine free radical ability, showing stronger antioxidant capacity; polysaccharide is one of the active components of chuanxiong, and by comparing the polysaccharides obtained by different drying methods, it is found that there is no difference in appearance, color and smell. , but the total sugar content was the highest under the condition of low temperature freeze-drying, the possible reason is that freeze-drying can protect its biological activity to the greatest extent, and effectively inhibit the damage of polysaccharide conformation caused by the denaturation of sugar-binding protein under high temperature conditions]. Therefore, low temperature freeze-drying is one of the effective methods for processing medicines containing polysaccharides.

2. Volatile components Volatile oils are widely found in detoxifying and aromatizing wet traditional Chinese medicines, and their content directly affects the curative effect of the medicines. Under certain conditions, drying will affect the degree of volatilization, structural decomposition and variation of volatile oils.

High temperature has a greater impact on volatile components. Tang Wenwen et al. found that the composition and content of Angelica volatile oil changed significantly with the increase of temperature. Studies have shown that the loss of components in low-temperature freeze-drying may be related to the sublimation of water, and it is not suitable for drying drugs containing volatile components. However, some scholars have compared the effects of low-temperature freeze-drying method and other drying methods on drugs containing volatile components, and found that the volatile oil content obtained by freeze-drying method is the highest. The extraction rate of volatile oil from low temperature freeze-dried flower buds was the highest, and the order of antioxidant activity of volatile oil from high to low was freeze-drying > shade-drying > sun-drying > 55 ℃ drying. Therefore, further research is needed for the application of low-temperature freeze-drying technology in medicines containing volatile components.

Freeze dryers, 30kg,50kg,100kg

3. Flavonoids Flavonoids are the most concerned and important antioxidants existing in medicinal plants. This function is related to its structure and contains a large number of phenolic hydroxyl groups. The higher the temperature, the easier it is for flavonoids to be oxidized and decomposed, especially when the compound contains an aldehyde group. The mass fraction of total flavonoids in sea buckthorn extract (47.35 mg/g) was much higher than that in low-temperature drying (29.04 mg/g) or high-temperature drying (23.37 mg/g). The dynamic changes of flavonoids in the drying process of mulberry leaves were analyzed, and it was found that different drying conditions had a significant effect on the content of flavonoids. Microwave drying > Infrared drying.

4. Freeze-drying of other components can also better retain other components such as glycosides and proteins. For example, freeze-drying technology can reduce the activity of enzymes and inhibit the occurrence of hydrolysis. Li Min determined the content of verbascoside in freeze-dried Rehmannia glutinosa, raw ground and fresh ground, and found that the content of freeze-dried Rehmannia glutinosa is the highest, which is of great significance for clinical improvement of medicinal value. When comparing the effects of low-temperature freeze-drying and other drying methods on curcumin and other chemical components in turmeric, it was found that the curcumin and phenolic compounds in the turmeric prepared by low-temperature freeze-drying method had the highest content. The possible reason was that the activity of polyphenol oxidase increased with temperature. , and its activity can be effectively inhibited below 0 °C and in a vacuum environment. Some proteins are heat-sensitive proteins, which are easily affected by temperature and undergo structural changes at higher drying temperatures. The main active ingredient of Dilong is protein, and the vacuum freeze-drying process can retain its effective active ingredients to the greatest extent, and the content of soluble protein is not significantly different from that of raw materials.

Parameter:

Model	KFD-20	KFD-25	KFD-30	KFD-40	KFD-50	KFD-100	KFD-150	KFD-200
Capacity (Kg/Batch)	200	250	300	400	500	1000	1500	2000
Shelf Area (㎡)	20	25	400	40	52	102	152	201
Shelf Size (Mm)	2200*600	2200*600	3300*600	3300*600	3300*600	5000*600	10000*600	9900*600
Shelf Quantity (Layer)	8+1	10+1	8+1	10+1	13+1	17+1	13+1	17+1
Shelf Quantity (Piece)	18	22	18	18	28	36	28	36
Space Between（Mm）	95
Shelf Temperature (℃)	room to 120
Water Catcher Temper (℃)	-65±5
Max Catch Water（Kg）	300	380	450	600	750	1500	2200	3000
Ultimate Vacuum （Pa）	5
Electricity（Kw）	63	72	101	116	168	232	287	384

Pre-sale:

* As soon as we get your inquiry, we will always reply to your email on time and try our best to recommend you the most suitable freeze dryer. Detailed tech info will also be provided for you.

* We can do sample tests for customers.

After-sale:

* If possible, please do come to our factory and we will teach workers the whole process of freeze-drying. The most appropriate time needed for freeze-drying will be tested by us.

* We will keep in touch with you, to make sure every part of the freeze dryer works well. One-year warranty, free online service for abroad customers.